Estranor Tablets 2mg/0.5mg (Estradiol Valerate , Nrgestreol) – saffron pharmaceutical

Uses & Indications

Hormone Replacement Therapy (HRT) is prescribed to relieve symptoms caused by reduced estrogen levels during perimenopause and menopause. It helps improve quality of life by replacing hormones that the body naturally produces in lower amounts.

It is commonly used for:

Relief of hot flashes and night sweats
Management of vaginal dryness and discomfort
Reduction of mood swings and irritability
Improvement of sleep disturbances associated with menopause
Treatment of irregular menstrual cycles during the menopausal transition
Prevention of postmenopausal bone loss (osteoporosis) in selected women
How It Works

This medicine contains estradiol (estrogen) along with progestogen. Estradiol replaces the estrogen that naturally declines during menopause, helping to relieve symptoms such as hot flashes, vaginal dryness, and mood changes.

The added progestogen protects the lining of the uterus (endometrium) by regulating menstrual bleeding and significantly reducing the risk of endometrial (uterine) cancer that may occur with estrogen-only therapy in women who still have a uterus.

Usage & Safety
Dosage

Adults: Take one estradiol tablet daily for 11 days, followed by one combined estradiol/progestogen tablet daily for the next 10 days, then have 7 tablet-free days before starting the next cycle. Treatment is generally started on the 5th day of the menstrual cycle, or as advised by your physician.

Children: Not applicable.

Always use this medicine exactly as prescribed by your healthcare provider.

Possible Side Effects
Common
Headache
Nausea
Abdominal pain
Weight gain or weight loss
Skin rash or itching
Breast tenderness
Irregular vaginal bleeding or spotting (usually improves with continued treatment)
Less Common
Allergic reactions
Dizziness
Depression or mood changes
Palpitations
Indigestion
Fluid retention (edema)
Hives (urticaria)
Breast pain
Visual disturbances
Rare
Anxiety
Migraine
Changes in sexual desire (libido)
Acne
Excessive hair growth
Muscle cramps
Painful periods
Vaginal discharge
Breast swelling
Fatigue
Contact lens intolerance

Seek immediate medical attention if you experience severe allergic reactions, chest pain, sudden shortness of breath, or signs of a blood clot.

Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may reduce the effectiveness of HRT or increase side effects:

Anti-epileptic medicines (e.g., phenytoin, phenobarbital)
Antibiotics (e.g., rifampicin, rifabutin)
HIV medicines, including protease inhibitors
Non-nucleoside reverse transcriptase inhibitors (e.g., nevirapine, efavirenz)
Herbal products containing St. John’s Wort (Hypericum)
Medicines used to treat diabetes, including insulin
Indications

This two-phase hormonal therapy is indicated for:

Menopause-related symptoms
Perimenopausal hormonal imbalance
Irregular menstrual cycles caused by hormonal deficiency
Hormone replacement in women with estrogen deficiency
When Not to Use

Do not use this medicine if you:

Are allergic to estradiol, progestogen, or any ingredient in the formulation
Have or have had breast cancer
Have cancer of the uterus (endometrial cancer)
Have unexplained vaginal bleeding
Have untreated endometrial hyperplasia
Have a history of deep vein thrombosis (DVT), pulmonary embolism (PE), or other blood clotting disorders
Have severe liver disease unless approved by your physician
Precautions

Use this medicine only under regular medical supervision.

Stop taking the medicine immediately and seek medical attention if you develop:

Painful swelling or redness in one leg
Sudden chest pain
Difficulty breathing
Sudden loss of vision
Severe headache or weakness on one side of the body

Regular breast examinations, pelvic check-ups, and routine health screenings are recommended during treatment.

Warnings

Heart Disease:
Hormone Replacement Therapy is generally not recommended for women with current or recent heart disease. Discuss your medical history with your healthcare provider before starting treatment.

Cancer Risk:
Tell your doctor if you or a close family member has a history of breast, ovarian, or uterine cancer, as HRT may not be suitable for everyone.

Ovarian Cancer:
Long-term use of estrogen-containing HRT has been associated with a small increase in the risk of ovarian cancer. Your doctor will evaluate the benefits and risks before initiating long-term therapy.

Pregnancy & Breastfeeding

This medicine is not intended for use during pregnancy. If pregnancy occurs while taking this medicine, stop treatment and contact your doctor immediately.

Always consult your physician before using any medicine during pregnancy or breastfeeding.

Storage

Store at room temperature (below 25–30°C) in a cool, dry place, away from direct sunlight, heat, and moisture. Keep out of the reach of children.